The Se Cathedral of Santa Catarina in Old Goa, is the largest church in India, dedicated to Catherine of Alexandria. It is the cathedral of the Latin Rite Catholic Archdiocese of Goa and Daman, and the seat of the Patriarch of the East Indies. It is one of the oldest and most celebrated religious buildings in Goa and is one of the largest churches in Asia.

The Se Cathedral was built to commemorate the victory of the Portuguese under Afonso de Albuquerque over a Muslim army, leading to the capture of the city of Goa in 1510. Since the day of the victory happened to be on the feast of Saint Catherine, the cathedral was dedicated to her.   

It was commissioned by Governor George Cabral to be enlarged in 1552 on the remains of an earlier structure. The actual construction began in 1562 under the reign of King Dom Sebastiao. The Cathedral was finally completed in 1619 and was consecrated in 1640.

It originally had two towers, but one collapsed in 1776 and was never rebuilt.